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Corrected calcium adjusts total serum calcium levels based on albumin, a blood protein that binds calcium. Since low albumin (e.g., in malnutrition, liver disease, or inflammation) can falsely lower total calcium, correction reveals the biologically active calcium available for physiological functions. This prevents misdiagnosis of hypo/hypercalcemia.
The most common formula is:
Corrected Calcium (mg/dL) = Total Calcium + 0.8 × (4.0 – Serum Albumin)
Example: If total calcium = 8.5 mg/dL and albumin = 2.5 g/dL:
8.5 + 0.8 × (4.0 – 2.5) = 9.7 mg/dL (normal range: 8.5–10.2 mg/dL).
Low albumin levels (<4.0 g/dL).
Conditions like cirrhosis, nephrotic syndrome, or critical illness.
Pre-surgical evaluations or monitoring calcium disorders.
If albumin is ≥4.0 g/dL, correction is unnecessary. The calculator will note this and display total calcium as-is.
~40–50% of serum calcium binds to albumin. Low albumin reduces total calcium but not ionized (free) calcium, which regulates muscle/nerve function. Correction estimates ionized calcium indirectly.
Total calcium: Includes bound and free forms.
Corrected calcium: Estimates free calcium when albumin is abnormal.
Ionized calcium: Directly measures active calcium (gold standard but requires specialized tests).
False hypocalcemia: May lead to unnecessary IV calcium or supplements.
Missed hypercalcemia: High ionized calcium (e.g., hyperparathyroidism) could be overlooked if total calcium appears normal due to low albumin.
It’s a close estimate but not perfect. For critical cases (e.g., ICU patients), ionized calcium tests are preferred.
Hypocalcemia: <8.5 mg/dL (may cause tetany, seizures).
Hypercalcemia: >10.2 mg/dL (risks kidney stones, arrhythmias).
The calculator flags abnormal results.
Yes. Hemoconcentration (e.g., from dehydration) can elevate albumin, making total calcium appear falsely high. Always assess hydration status.
Loop diuretics (e.g., furosemide): Increase calcium excretion.
Thiazides: Reduce excretion (may cause hypercalcemia).
Vitamin D analogs: Elevate calcium absorption.
Hypoparathyroidism
Vitamin D deficiency
Chronic kidney disease
Magnesium deficiency
Hyperparathyroidism
Malignancy (bone metastases)
Excess vitamin D or calcium supplements
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